Category Archives: Research

A comprehensive list of the published research studies on the multiple benefits and possibilities of sea cucumber extracts.

Differential Effects of 2 Sea Cucumber Extracts on Caspase Activation and Apoptosis of Human Leukemia Cells

Both Frondoside A and Cucumarioside A2-2 are extracts from sea cucumbers.  Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A2-2 is a pentaoside having glucose as a third monosaccahride unit. The effects of Frondoside A and A2-2 for cell death-inducing capability with … Continue reading Differential Effects of 2 Sea Cucumber Extracts on Caspase Activation and Apoptosis of Human Leukemia Cells

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Chemopreventive Effects of a Sea Cucumber Extract against Rat Colon Carcinogenesis and Inhibition of Human Colon Cancer Cell Growth

Sea cucumber extracts have been widely used to treat individuals with inflammatory conditions in East Asia.  The present study has been designed to test potential colon cancer–preventive properties of Frondanol A5, a glycolipid extract from the sea cucumber using in vivo and in vitro models of colon cancer. Chemopreventive efficacy of Frondanol A5 was evaluated … Continue reading Chemopreventive Effects of a Sea Cucumber Extract against Rat Colon Carcinogenesis and Inhibition of Human Colon Cancer Cell Growth

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Improved Immune Responses by a Sea Cucumber Extract to Prevent Intestinal Tumorigenesis

Oxidative stress is a common mechanism contributing to the initiation and progression of hepatic damage.  The aim of the present study is to evaluate the efficacy of sea cucumber extract as an antioxidant against 7,12-dimethylbenz[a]anthracene- (DMBA-) induced hepatorenal dysfunction.  Single oral administration of DMBA (15 mg/kg body weight) to Wistar rats resulted in a significant increase … Continue reading Improved Immune Responses by a Sea Cucumber Extract to Prevent Intestinal Tumorigenesis

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Anti-Fibrotic Effect of Sea Cucumber Extract

The present study assesses the anti-oxidative and anticholestatic effects of the sea cucumber Holothuria arenicola extract (HaE) in a model of bile duct ligation in male albino rats.  The HaE revealed significant antifibrotic effect as evident by decreasing the levels of total conjugated and unconjugated bilirubin and the activities of serum aminotransferases (ASAT and ALAT) … Continue reading Anti-Fibrotic Effect of Sea Cucumber Extract

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Sea Cucumber Extract as a Systemic Modulator of Human Bone Metabolism

In vitro studies utilizing extract of sea cucumber to elucidate its effects on cell viability and functional activity were performed.  It was found an inverse relationship between sea cucumber extract concentration and its effect on osteoblast cell viability.  There was a trend towards increased osteoblast cell function in the presence of sea cucumber extract.  Sea … Continue reading Sea Cucumber Extract as a Systemic Modulator of Human Bone Metabolism

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Sea Cucumbers Metabolites as Potent Anti-Cancer Agents

Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases.  Sea cucumber extracts are being studied for their anti-inflammatory functions, immunostimulatory properties, and for cancer prevention and treatment.  There is large scope for … Continue reading Sea Cucumbers Metabolites as Potent Anti-Cancer Agents

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High-Value Components & Bioactives from Sea Cucumbers

Sea cucumbers are marine invertebrates, habitually found in the benthic areas and deep seas across the world.  Sea cucumbers, informally named as bêche-de-mer, or gamat, have long been used for food and folk medicine in the communities of Asia and Middle East.  Nutritionally, sea cucumbers have an impressive profile of valuable nutrients such as Vitamin … Continue reading High-Value Components & Bioactives from Sea Cucumbers

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Anticancer Activity of Sea Cucumber

Triterpene glycosides are characteristic secondary metabolites of sea cucumbers. They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell lines in vitro and, more importantly, intraperitoneal administration in rodents of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor … Continue reading Anticancer Activity of Sea Cucumber

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Sea Cucumber Extract’s Suppressive Effects on Lung Cancer

A major challenge for oncologists and pharmacologists is to develop less toxic drugs that will improve the survival of lung cancer patients. Frondoside A is a triterpenoid glycoside isolated from the sea cucumber, Cucumaria frondosa and was shown to be a highly safe compound. The impact of Frondoside A on survival, migration and invasion in … Continue reading Sea Cucumber Extract’s Suppressive Effects on Lung Cancer

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